Clinical Trials

Endorsed Trials

Title: IDEAL Partnership – Improved cardiovascular Disease hEALth service delivery in Australia

Status: In development

Summary: The IDEAL study aims to improve the way doctors manage patients’ risk of cardiovascular disease, including conditions such as heart attack or stroke. This research focuses on the development of a new service to calculate cardiovascular risk and deliver this information to GPs to help them make well-informed treatment decisions around risk management to improve outcomes for their patients.

For more information contact: Prof James Sharman, Chief Investigator – james.sharman@utas.edu.au or visit the Ideal Study website

Title: Metformin Aneurysm Trial 

Status: Funded

Summary: Metformin Aneurysm Trial is a multicentre, randomised, placebo-controlled trial to assess if 1500 mg of metformin per day will reduce Abdominal Aortic Aneurysm (AAA)-related events in patients with small AAAs who do not have diabetes.

For more information contact: Sophie Rowbotham, Global Trial Manager – sophie.rowbotham@jcu.edu.au

Title: COLCARDIO-ACS –  Cardiovascular Outcomes in Acute Coronary Syndrome trial

Status: Funded

Summary: The aim of this trial is to assess the effect of colchicine (0.5 mg/day) in addition to optimal medical therapy on cardiovascular outcomes in ACS patients with evidence of persistent coronary inflammation (based on hsCRP). We hypothesise that addition of colchicine to optimal medical therapy in patients post-ACS, who have biomarker evidence of persistent inflammation will reduce recurrent cardiovascular events.

For more information contact: Annie Yeung, Project Manager – colcardio-acs@ctc.usyd.edu.au

Title: EASY-AS – The Early valve replacement in severe ASYmptomatic aortic stenosis trial

Status: Funded

Summary: In a large collaborative trial, the researchers in Australia will work with colleagues in the United Kingdom and in New Zealand to test the best strategy by randomising 2,844 patients with severe aortic stenosis. They will either undergo early valve replacement or a conventional approach of regular close follow-up, with surgery recommended if and when symptoms develop.

For more information contact: Prof Graham Hillis, Chief Investigator – Graham.Hillis@health.wa.gov.au

Title: QUEL – Quality improvement in primary care to prevent hospitalisations and improve Effectiveness and efficiency of care for people Living with heart disease 

Status: Recruiting

Summary: Heart disease accounts for a great number of deaths and admissions to hospital. We aim to improve ongoing prevention for people with heart disease by supporting general practices to use their data and provide more systematic care. We propose a randomised trial to determine whether a practice level strategy reduces cardiovascular events and hospitalisations and saves money. The research will directly inform government decision-making and policy regarding primary care incentive payment programs.

For more information contact: Prof Julie Redfern, Chief Investigator – julie.redfern@sydney.edu.au

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